Smith was picked off again by Freeman in the end zone midway through the fourth quarter, and then the quarterback fumbled the ball away with 3:24 left to seal the game.
"The way we opened up, marching down the way we did, it felt like things were going to be the way they've been," Smith said. "We really didn't get into a rhythm after that, didn't execute in any area, and then the turnovers. The turnovers hurt you."
The Colts started their seventh offensive line combination and fifth in five games.